Connexin 32 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP1551b
Background:
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.GJB1 is normally found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells in the peripheral nervous system, as well as in oligodendrocytes and their processes, but not in compact myelin of the central nervous system. A series of mutational and other studies have directly linked defects in GJB1 to X-linked Charcot-Marie-Tooth disease (CMTX), a clinically and genetically heterogeneous group of hereditary motor and sensory peripheral neuropathies.
Other Names:
Gap junction beta-1 protein, Connexin-32, Cx32, GAP junction 28 kDa liver protein, GJB1, CX32
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1551b was selected from the C-term region of human GJB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GJB1
Gene ID: 2705
Primary Accession: P08034
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.GJB1 is normally found in the paranodal myelin loops and Schmidt-Lanterman incisures of myelinating Schwann cells in the peripheral nervous system, as well as in oligodendrocytes and their processes, but not in compact myelin of the central nervous system. A series of mutational and other studies have directly linked defects in GJB1 to X-linked Charcot-Marie-Tooth disease (CMTX), a clinically and genetically heterogeneous group of hereditary motor and sensory peripheral neuropathies.
Other Names:
Gap junction beta-1 protein, Connexin-32, Cx32, GAP junction 28 kDa liver protein, GJB1, CX32
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1551b was selected from the C-term region of human GJB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: GJB1
Gene ID: 2705
Primary Accession: P08034
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review