Connexin 43 (phospho-S367) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4777
Background:
Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication.
Alternative Name:
Gap junction alpha-1 protein, Connexin-43, Connexin 43, Connexin43, Cx43, Cx-43, Gap junction 43 kDa heart protein, GJA1, GJAL
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-Connexin 43 (S367) polyclonal antibody detects endogenous levels of Connexin 43 protein when phosphorylated at Ser367.
Immunogen:
Synthetic phosphopeptide derived from human Connexin 43 around the phosphorylation site of Serine 367.
MW: ~ 43 kDa
Swis Prot.: P17302
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication.
Alternative Name:
Gap junction alpha-1 protein, Connexin-43, Connexin 43, Connexin43, Cx43, Cx-43, Gap junction 43 kDa heart protein, GJA1, GJAL
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-Connexin 43 (S367) polyclonal antibody detects endogenous levels of Connexin 43 protein when phosphorylated at Ser367.
Immunogen:
Synthetic phosphopeptide derived from human Connexin 43 around the phosphorylation site of Serine 367.
MW: ~ 43 kDa
Swis Prot.: P17302
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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