COPS5 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP8867b
Background:
The protein is one of the eight subunits of COP9 signalosome, a highly onserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Other Names:
COP9 signalosome complex subunit 5, SGN5, Signalosome subunit 5, 34--, Jun activation domain-binding protein 1, COPS5, CSN5, JAB1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8867b was selected from the C-term region of human COPS5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: COPS5
Gene ID: 10987
Primary Accession: Q92905
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein is one of the eight subunits of COP9 signalosome, a highly onserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Other Names:
COP9 signalosome complex subunit 5, SGN5, Signalosome subunit 5, 34--, Jun activation domain-binding protein 1, COPS5, CSN5, JAB1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8867b was selected from the C-term region of human COPS5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: COPS5
Gene ID: 10987
Primary Accession: Q92905
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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