COPS7A polyclonal (C-term), anti-human
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AC-AP12810b
Catalog Number: AC-AP12810b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB32335
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB32335
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Other Names:
COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
Target/Specificity:
This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Antigen Region:
237-266
Antigen Type: Synthetic Peptide
Gene Name: COPS7A
Gene ID: 50813
Primary Accession: Q9UBW8
NCBI Accession: NP_001157565.1;NP_001157566.1;NP_001157567.1;NP_057403.1
Other Accession: Q9CZ04; NP_057403.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Other Names:
COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
Target/Specificity:
This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Antigen Region:
237-266
Antigen Type: Synthetic Peptide
Gene Name: COPS7A
Gene ID: 50813
Primary Accession: Q9UBW8
NCBI Accession: NP_001157565.1;NP_001157566.1;NP_001157567.1;NP_057403.1
Other Accession: Q9CZ04; NP_057403.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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