COPS8 Polyclonal Antibody

Background:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Research Area: Cancer, Cell Biology, Developmental Biology, Immunology, Signal Transduction, Stem Cells

Synonyms:
COPS8, COP9, CSN8, SGN8

Immunogen: Recombinant fusion protein of human COPS8 (NP_006701.1).

Swissprot: Q99627
Gene ID: 10920

Calculated MW: 17 kDa/23 kDa
Observed MW: 23 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.