COQ3 polyclonal (Center), anti-human

Background:
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. COQ3 is an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.

Other Names:
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial, 2-polyprenyl-6-hydroxyphenol methylase,4-dihydroxy-5-hexaprenylbenzoate methyltransferase, DHHB methyltransferase, DHHB-MT, DHHB-MTase, 3-demethylubiquinone-10 3-methyltransferase, Dihydroxyhexaprenylbenzoate methyltransferase, COQ3

Target/Specificity:
This COQ3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-201 amino acids from the Central region of human COQ3.

Antigen Region:
172-201

Antigen Type: Synthetic Peptide

Gene Name: COQ3 {ECO:0000255|HAMAP-Rule:MF_03190}
Gene ID: 51805
Primary Accession: Q9NZJ6
NCBI Accession: NP_059117.3
Other Accession: Q3T131
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.