Cortactin monoclonal(Ascites), anti-human
€470.00
In stock
SKU
AC-AM2001a
Catalog Number: AC-AM2001a
Size: 100 µl
Isotype: mouse IgM
Clone Name: 401CT8.6.3
Applications: WB
Datasheet
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Size: 100 µl
Isotype: mouse IgM
Clone Name: 401CT8.6.3
Applications: WB
Datasheet
Request Information
Background:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Other Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Target/Specificity:
Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: CTTN
Gene ID: 2017
Primary Accession: Q14247
NCBI Accession: NP_001171669.1;NP_005222.2;NP_612632.1
Other Accession: NP_005222.2
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Other Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Target/Specificity:
Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody.
Antigen Type: Recombinant Protein
Gene Name: CTTN
Gene ID: 2017
Primary Accession: Q14247
NCBI Accession: NP_001171669.1;NP_005222.2;NP_612632.1
Other Accession: NP_005222.2
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
| Is Featured? | No |
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