Cox-3 polyclonal, anti-mouse antibody
€275.00
In stock
SKU
AC-ABV10520-100
Catalog Number: AC-ABV10520-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory dr µgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions thro µghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been s µggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.
Other Names:
PTGS1 , PCOX1 , COX-3 , COX3 , PGHS1 , PGHS-1 , PHS1 , PTGHS
Primary Accession: P22437
Gene Name: Ptgs1
Gene ID: 19224
Concentration (mg/ml): 0.5 mg/ml
COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory dr µgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions thro µghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been s µggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.
Other Names:
PTGS1 , PCOX1 , COX-3 , COX3 , PGHS1 , PGHS-1 , PHS1 , PTGHS
Primary Accession: P22437
Gene Name: Ptgs1
Gene ID: 19224
Concentration (mg/ml): 0.5 mg/ml
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