COX1/Cyclooxygenase 1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase(PTGS1) or mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40 kb long, with 11 protein-coding exons. There were 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, Funk et al.(1991) demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

Description:
Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 1 (PTGS1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
COX 1 antibody, COX 3 antibody, COX-1 antibody, COX1 antibody, COX3 antibody, Cyclooxygenase 1 antibody, Cyclooxygenase 3, included antibody, Cyclooxygenase-1 antibody, Cyclooxygenase1 antibody, EC 1.14.99.1 antibody, Partial COX1 proteins, included antibody, PCOX 1 antibody, PCOX1 antibody, PGG/HS antibody, PGH synthase 1 antibody, PGH1_HUMAN antibody, PGHS 1 antibody, PGHS-1 antibody, PGHS1 antibody, PHS 1 antibody, PHS1 antibody, Prostaglandin endoperoxide synthase 1 antibody, Prostaglandin G/H synthase 1 antibody, Prostaglandin G/H synthase and cyclooxygenase antibody, Prostaglandin H Synthase 1 antibody, Prostaglandin H2 synthase 1 antibody, Prostaglandin-endoperoxide synthase 1(prostaglandin G/H synthase and cyclooxygenase) antibody, Prostaglandin-endoperoxide synthase 1 antibody, PTGHS antibody, PTGS 1 antibody, PTGS1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human COX1(35-52aa CCYYPCQHQGICVRFGLD), different from the related rat and mouse sequences by two amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human COX1(35-52aa CCYYPCQHQGICVRFGLD), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.