COX1 polyclonal, anti-human, mouse, rat

Background:
Cytochrome c oxidase subunit I, COX1 (also designated COI, MTCO1 or oxidative phosphorylation (OxPhos) Complex IV, subunit I) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1-3) of respiratory Complex IV. Cytochrome c oxidase is a hetero-oligomeric enzyme composed of 13 subunits localized to the mitochondrial inner membrane and is the terminal enzyme complex of the electron transport chain. Complex IV catalyzes the reduction of molecular oxygen to water. The energy released is used to transport protons across the mitochondrial inner membrane. The resulting electro-chemical gradient is necessary for the synthesis of ATP. Complex IV contains 13 polypeptides, COX1, COX2 and COX3 (MTCO1-3) make up the catalytic core and are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc and VIII are nuclear-encoded.

Alternative Name:
COX-1, PGH synthase 1, PGHS-1, PHS 1, PTGS1, COX 1, COX 3, COX-1, COX1, Cox3, Cyclooxygenase 1, Cyclooxygenase 3, included, Cyclooxygenase-1, EC 1.14.99.1, Partial COX1 proteins, included, PCOX1, PGG/HS, PGH synthase 1, PGH1, PGHS-1, PGHS1, PHS 1, PHS1, Prostaglandin G/H synthase 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 1, PTGHS, PTGS1,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: COX1 polyclonal antibody detects endogenous levels of COX1 protein.

Immunogen:
recombinant protein

MW: 69 kDa

Swiss-Prot: P23219(Human) P22437(Mouse) Q63921(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.