COX10 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP10714b
Background:
Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes heme A:farnesyltransferase, which is not a structuralsubunit but required for the expression of functional COX andfunctions in the maturation of the heme A prosthetic group of COX.This protein is predicted to contain 7-9 transmembrane domainslocalized in the mitochondrial inner membrane. A gene mutation,which results in the substitution of a lysine for an asparagine(N204K), is identified to be responsible for cytochrome c oxidasedeficiency. In addition, this gene is disrupted in patients withCMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP(hereditary neuropathy with liability to pressure palsies)deletion.
Other Names:
Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
Gene Name: COX10
Gene ID: 1352
Primary Accession: Q12887
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes heme A:farnesyltransferase, which is not a structuralsubunit but required for the expression of functional COX andfunctions in the maturation of the heme A prosthetic group of COX.This protein is predicted to contain 7-9 transmembrane domainslocalized in the mitochondrial inner membrane. A gene mutation,which results in the substitution of a lysine for an asparagine(N204K), is identified to be responsible for cytochrome c oxidasedeficiency. In addition, this gene is disrupted in patients withCMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP(hereditary neuropathy with liability to pressure palsies)deletion.
Other Names:
Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
Gene Name: COX10
Gene ID: 1352
Primary Accession: Q12887
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review