COX17 antibody (clone 4G2), anti-human
€435.00
In stock
SKU
AC-AT1597a
Catalog Number: AC-AT1597a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, E
Request Information AC-AT1597a">Request Information
Background:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Other Names:
Cytochrome c oxidase copper chaperone, COX17
Antigen Type:
Recombinant Protein
Gene Name: COX17
Gene ID: 10063
NCBI Accession: NP_005685.1
Primary Accession: Q14061
Other Accession: NM_005694
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
Other Names:
Cytochrome c oxidase copper chaperone, COX17
Antigen Type:
Recombinant Protein
Gene Name: COX17
Gene ID: 10063
NCBI Accession: NP_005685.1
Primary Accession: Q14061
Other Accession: NM_005694
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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