COX17 Polyclonal Antibody

Background:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
COX 17, COX17, COX17 cytochrome c oxidase assembly homolog (S. cerevisiae), COX17 cytochrome c oxidase assembly homolog, COX17 homolog cytochrome c oxidase assembly protein, COX17, cytochrome c oxidase assembly protein cox17 homolog, Cytochrome c oxidase copper chaperone, Human homolog of yeast mitochondrial copper recruitment, MGC104397, MGC117386, OTTHUMP00000215284, OTTHUMP00000215285

Immunogen: Synthetic peptide of human COX17

Swissprot: Q14061
Gene Accession: NP005685

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:2000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.