COX2/Cyclooxygenase 2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Cyclooxygenase(Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.

Description:
Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 2 (PTGS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
COX 2 antibody, COX-2 antibody, COX2 antibody, Cyclooxygenase 2 antibody, Cyclooxygenase 2b antibody, Cyclooxygenase antibody, Cyclooxygenase-2 antibody, Cyclooxygenase2 antibody, EC 1.14.99.1 antibody, fj02a10 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody, GRIPGHS antibody, hCox 2 antibody, Macrophage activation-associated marker protein P71/73 antibody, OTTHUMP00000033524 antibody, PES-2 antibody, PGG/HS antibody, PGH synthase 2 antibody, PGH2_HUMAN antibody, PGHS 2 antibody, PGHS-2 antibody, PGHS2 antibody, PHS 2 antibody, PHS II antibody, PHS2 antibody, Prostaglandin endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase) antibody, Prostaglandin endoperoxide synthase 2 antibody, Prostaglandin G/H synthase 2 antibody, Prostaglandin G/H synthase 2 precursor antibody, Prostaglandin G/H synthase and cyclooxygenase antibody, Prostaglandin G/H synthase antibody, Prostaglandin H2 synthase 2 antibody, prostaglandin-endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase antibody, Prostaglandin-endoperoxide synthase 2 antibody, PTGS2 antibody, ptgs2a antibody, TIS10 antibody, TIS10 protein antibody, unp1239 antibody, wu:fj02a10 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human COX2(26-41aa CQNRGVCMSVGFDQYK), different from the related rat sequence by two amino acids.A synthetic peptide corresponding to a sequence at the N-terminus of human COX2(26-41aa CQNRGVCMSVGFDQYK), different from the related rat sequence by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.