COX6A2 Polyclonal Antibody

Background:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity.

Research Area: Cancer, Metabolism, Signal transduction

Synonyms:
COX VIa M, COX6AH, COXVIAH, Cytochrome c oxidase polypeptide VIa heart, Cytochrome c oxidase subunit 6A2 mitochondrial, Cytochrome c oxidase subunit VIA muscle, Cytochrome c oxidase subunit VIa polypeptide 2, MS411

Immunogen: Synthetic peptide of human COX6A2

Swissprot: Q02221
Gene Accession: NP005196

Calculated MW: 11 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.