Coxsackie Adenovirus Receptor polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CXADR(Coxsackie virus and adenovirus receptor) is a protein that in humans is encoded by the CXADR gene, also known as CAR,CVB3-binding protein, Coxsackievirus B-adenovirus receptor. The CAR cDNA encodes a predicted 365-amino acid polypeptide that contains a single transmembrane domain and is a member of the immunoglobulin superfamily. By Northern blot analysis, they detected highest expression of 1.4-kb and 6-kb CXADR transcripts in pancreas, brain, heart, small intestine, testis, and prostate, lower expression in liver and lung, and no expression in kidney, placenta, peripheral blood leukocytes, thymus, and spleen. In comparison, mouse Cxadr showed highest expression in liver, and lower levels in kidney, heart, lung, and brain. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins, such as: fibronectin, agrin, laminin-1 and tenascin-R.

Description:
Rabbit IgG polyclonal antibody for Coxsackievirus and adenovirus receptor (CXADR) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
46 kD coxsackievirus and adenovirus receptor CAR protein antibody, 46 kD coxsackievirus and adenovirus receptor protein antibody, CAR antibody, CAR4/6 antibody, Coxsackie virus and adenovirus receptor antibody, Coxsackie virus B receptor antibody, Coxsackievirus and adenovirus receptor antibody, Coxsackievirus B adenovirus receptor antibody, Coxsackievirus B-adenovirus receptor antibody, CVB3 binding protein antibody, CVB3-binding protein antibody, Cxadr antibody, CXAR_HUMAN antibody, hCAR antibody, HCVADR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Coxsackie Adenovirus Receptor(313-328aa YSKTQYNQVPSEDFER), identical to the related rat and mouse sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human Coxsackie Adenovirus Receptor(313-328aa YSKTQYNQVPSEDFER), identical to the related rat and mouse sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.