CPT1A polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7744
Background:
The mitochondrial β-oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase (CPT) I (outer membrane and detergent labile) and II (inner membrane and detergent stable), together with carnitine carrier. CPTI catalyzes the first reaction in the transport of long-chain fatty acids from the cytoplasm to the mitochondrion, a rate-limiting step in beta-oxidation. Two types of CPTI are known, the liver (CPTIA) and muscle (CPTIB) isoforms. The muscle type protein is specially expressed in heart and skeletal muscle. Membrane-bound CPTI, but not CPTII, is inhibited reversibly by malonyl-coenzyme A (CoA). Unlike CPTII, CPTI requires membrane integrity for catalytic function. In addition, glutamic acid 3 and histidine 5 are necessary for malonyl CoA inhibition and binding to liver CPTI, but not for catalytic activity.
Alternative Name:
Carnitine O palmitoyltransferase 1 liver isoform, Carnitine O palmitoyltransferase I, Carnitine O palmitoyltransferase I liver isoform, Carnitine O-palmitoyltransferase 1, Carnitine O-palmitoyltransferase I, Carnitine palmitoyltransferase 1A (liver), Carnitine palmitoyltransferase 1A, Carnitine palmitoyltransferase I, Carnitine palmitoyltransferase I liver, CPT 1, CPT I, CPT1, CPT1 L, CPT1-L, Cpt1a, CPT1A_HUMAN, CPTI, CPTI-L, L CPT1, liver isoform,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200, IP 1:50 - 1:100
Specificity: CPT1A polyclonal antibody detects endogenous levels of CPT1A protein.
Immunogen:
Recombinant full length Human CPT1A.
MW: ~ 88 kDa
Swis Prot.: P50416
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The mitochondrial β-oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase (CPT) I (outer membrane and detergent labile) and II (inner membrane and detergent stable), together with carnitine carrier. CPTI catalyzes the first reaction in the transport of long-chain fatty acids from the cytoplasm to the mitochondrion, a rate-limiting step in beta-oxidation. Two types of CPTI are known, the liver (CPTIA) and muscle (CPTIB) isoforms. The muscle type protein is specially expressed in heart and skeletal muscle. Membrane-bound CPTI, but not CPTII, is inhibited reversibly by malonyl-coenzyme A (CoA). Unlike CPTII, CPTI requires membrane integrity for catalytic function. In addition, glutamic acid 3 and histidine 5 are necessary for malonyl CoA inhibition and binding to liver CPTI, but not for catalytic activity.
Alternative Name:
Carnitine O palmitoyltransferase 1 liver isoform, Carnitine O palmitoyltransferase I, Carnitine O palmitoyltransferase I liver isoform, Carnitine O-palmitoyltransferase 1, Carnitine O-palmitoyltransferase I, Carnitine palmitoyltransferase 1A (liver), Carnitine palmitoyltransferase 1A, Carnitine palmitoyltransferase I, Carnitine palmitoyltransferase I liver, CPT 1, CPT I, CPT1, CPT1 L, CPT1-L, Cpt1a, CPT1A_HUMAN, CPTI, CPTI-L, L CPT1, liver isoform,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200, IP 1:50 - 1:100
Specificity: CPT1A polyclonal antibody detects endogenous levels of CPT1A protein.
Immunogen:
Recombinant full length Human CPT1A.
MW: ~ 88 kDa
Swis Prot.: P50416
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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