Cerebral 1 polyclonal, anti-human
€470.00
In stock
SKU
AC-AP69055
Catalog Number: AC-AP51114
Size: 100 µl
Host: Rabbit
Applications: WB, ICC, IHC-P, E
Datasheet
Request Information
Size: 100 µl
Host: Rabbit
Applications: WB, ICC, IHC-P, E
Datasheet
Request Information
Background:
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Other Names:
RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin
Antigen Type: synthetic peptide
Antigen Type: RRP8
Gene ID: 23378
Primary Accession: O43159
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Other Names:
RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin
Antigen Type: synthetic peptide
Antigen Type: RRP8
Gene ID: 23378
Primary Accession: O43159
| Is Featured? | No |
|---|
Write Your Own Review