CRADD Polyclonal Antibody

Background:
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Cell Biology

Synonyms:
CRADD, MRT34, RAIDD

Immunogen: Recombinant fusion protein of human CRADD (NP_003796.1).

Swissprot: P78560
Gene ID: 8738

Calculated MW: 11 kDa/22 kDa
Observed MW: 22 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.