CREB (Phospho-S133) polyclonal, anti-human, mouse

Background:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Alternative Name:
CREB-1, cAMP-responsive element-binding protein 1, Active transcription factor CREB, cAMP response element binding protein 1, cAMP response element binding protein, cAMP responsive element binding protein 1, cAMP-responsive element-binding protein 1, CREB, CREB-1, CREB1, CREB1, Cyclic AMP-responsive element-binding protein 1, MGC9284, OTTHUMP00000163864, OTTHUMP00000163865, OTTHUMP00000206660, OTTHUMP00000206662, OTTHUMP00000206667, Transactivator protein,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:100
IHC:1:50-1:200
FC:1:50-1:100
IP:1:10-1:50

Specificity: CREB (Phospho-S133) polyclonal antibody detects endogenous levels of CREB protein only when phosphorylated at S133.

Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Ser133 of human Creb.

MW: Predicted band size 37 kDa

Swiss-Prot: P16220(Human) Q01147(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.