CREBBP antibody (clone 2H5), anti-human
€435.00
In stock
SKU
AC-AT1621a
Catalog Number: AC-AT1621a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
Request Information AC-AT1621a">Request Information
Background:
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Other Names:
CREB-binding protein, CREBBP, CBP
Antigen Type:
Recombinant Protein
Gene Name: CREBBP (HGNC:2348)
Gene ID: 1387
NCBI Accession: NP_001073315.1;NP_004371.2
Primary Accession: Q92793
Other Accession: NM_004380
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Other Names:
CREB-binding protein, CREBBP, CBP
Antigen Type:
Recombinant Protein
Gene Name: CREBBP (HGNC:2348)
Gene ID: 1387
NCBI Accession: NP_001073315.1;NP_004371.2
Primary Accession: Q92793
Other Accession: NM_004380
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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