CRF rabbit polyclonal, anti-human, mouse, rat

Backgroud: This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation afunction:This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.,online information:Corticotropin-releasing hormone entry,similarity:Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.,

Synonyms: CRH, Corticoliberin, Corticotropin-releasing factor, CRF, Corticotropin-releasing hormone

Gene Name: CRH

Gene ID: 1392

SwissProt ID: P06850

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.