Crk p38 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CRK, also known as p38 or CRKII, is a protein that in humans is encoded by the CRK gene. This gene is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It is mapped to 17p13.3. The CRK protein participates in the Reelin signaling cascade downstream of DAB1. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Description:
Rabbit IgG polyclonal antibody for Adapter molecule crk (CRK) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
Adapter molecule crk antibody, Avian sarcoma virus CT10 (v crk) oncogene homolog antibody, CRK antibody, CRK isoform 2 antibody, CRK isoform II antibody, CRK_HUMAN antibody, CRKII antibody, FLJ38130 antibody, OTTHUMP00000115366 antibody, OTTHUMP00000198330 antibody, p38 antibody, Proto oncogene C crk antibody, Proto-oncogene C-crk antibody, v crk avian sarcoma virus CT10 oncogene homolog antibody, v crk sarcoma virus CT10 oncogene homolog antibody, v crk sarcoma virus CT10 oncogene homolog (avian) antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Crk p38 recombinant protein (Position: A2-R246). Human Crk p38 shares 99% and 100% amino acid (aa) sequences identity with mouse and rat Crk p38, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.