CRK polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Synonyms: p38, CRKII

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human CRK

Gene Symbol: CRK

Gene ID: 1398

Swiss prot: P46108

Calculated MW: 34kDa

Recommended dilution:
IHC 1:20-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.