CRK Polyclonal Antibody

Background:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Research Area: Cancer, Signal Transduction

Synonyms:
Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK, CRK isoform 2, CRK isoform II, CRK, CRKII, FLJ38130, OTTHUMP00000115366, OTTHUMP00000198330, p38, Proto oncogene C crk, Proto-oncogene C-crk, v crk avian sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog (avian)

Immunogen: Recombinant protein of human CRK

Swissprot: P46108
Gene Accession: BC009837

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-17989/sc-23775/sc-9004/sc-289