CRLF2 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.

Synonyms: CRL2, CRLF2Y, TSLPR

Cellular Location: Cell membrane Secreted Single-pass type I membrane protein

Immunogen:
Recombinant protein of human CRLF2

Gene Symbol: CRLF2

Gene ID: 64109

Swiss prot: Q9HC73

Calculated MW: 42kDa

Recommended dilution:
WB 1:200-1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.