CRM1 polyclonal, anti-human, mouse, rat

Background:
Protein transport across the nucleus is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha1 and karyopherin beta1 subunits. p62 glycoprotein is a nucleoporin that is not only involved in the nuclear import of proteins, but also the export of nascent mRNA strands. NTF2 (nuclear transport factor 2) interacts with nucleoporin p62 as a homodimer composed of two monomers, and may be an obligate component of functional p62. CRM1 has been shown to be an export receptor for leucine-rich proteins that contain the nuclear export signal (NES).

Alternative Name:
Exp1, XPO1, CRM1, Chromosome region maintenance 1 protein homolog, CRM 1, CRM1 homolog, DKFZp686B1823, emb, Exp 1, Exp1, Exportin 1, Exportin-1, Exportin1, XPO 1, xpo1, XPO1,

Application Dilution:
WB:1:500
ICC:1:50-1:200
IHC:1:50-1:100
FC:1:50-1:100

Specificity: CRM1 polyclonal antibody detects endogenous levels of CRM1 protein.

Immunogen:
Recombinant protein within C terminal human CRM1.

MW: 123 kDa

Swiss-Prot: O14980(Human) Q6P5F9(Mouse) Q80U96(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.