CRP polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6484
Background:
Pentraxins, which include C-reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Both Stat3 and C/EBP are involved in mouse SAP gene expression, but only Stat3 is involved in mouse CRP gene expression. SAP binds to a variety of molecules, including autoantigens and chromatin.
Alternative Name:
C reactive protein, C reactive protein pentraxin related, C-reactive protein(1-205), CRP, CRP, CRP, MGC88244, Pentraxin 1, PTX 1, PTX1,
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:200
Specificity: CRP polyclonal antibody detects endogenous levels of CRP protein.
Immunogen:
Recombinant full length Human CRP.
MW: ~ 25 kDa
Swis Prot.: P02741
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Pentraxins, which include C-reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Both Stat3 and C/EBP are involved in mouse SAP gene expression, but only Stat3 is involved in mouse CRP gene expression. SAP binds to a variety of molecules, including autoantigens and chromatin.
Alternative Name:
C reactive protein, C reactive protein pentraxin related, C-reactive protein(1-205), CRP, CRP, CRP, MGC88244, Pentraxin 1, PTX 1, PTX1,
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:200
Specificity: CRP polyclonal antibody detects endogenous levels of CRP protein.
Immunogen:
Recombinant full length Human CRP.
MW: ~ 25 kDa
Swis Prot.: P02741
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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