CRTC1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP9281a
Background:
CRTC1 is transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. This protein acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4, and regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.
Other Names:
CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1, Transducer of regulated cAMP response element-binding protein 1, TORC-1, Transducer of CREB protein 1, CRTC1 (HGNC:16062)
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9281a was selected from the N-term region of human CRTC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CRTC1 (HGNC:16062)
Gene ID: 23373
Primary Accession: Q6UUV9
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CRTC1 is transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. This protein acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4, and regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.
Other Names:
CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1, Transducer of regulated cAMP response element-binding protein 1, TORC-1, Transducer of CREB protein 1, CRTC1 (HGNC:16062)
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9281a was selected from the N-term region of human CRTC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CRTC1 (HGNC:16062)
Gene ID: 23373
Primary Accession: Q6UUV9
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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