CSK polyclonal (N-term), anti-human, mouse

Background:
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Other Names:
Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase CYL, CSK

Target/Specificity:
This CSK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 17-51 amino acids from the N-terminal region of human CSK.

Gene Name: CSK
Gene ID: 1445
Primary Accession: P41240
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.