p53 (C-terminus) monoclonal, anti-human
€470.00
In stock
SKU
AC-AP52665
Catalog Number: AC-AP55025
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IHC-F, IF, ICC, E
Datasheet
Request Information
Background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Other Names:
Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;Cys 51 Stop;FLJ92943;HGNC11998;LFS1; p53;p53 Cellular Tumor Antigen;p53 tumor suppressor;P53_HUMAN;Phosphoprotein p53;Tp53; Transformation related protein 53;TRP53;Tumor protein p53;Tumor suppressor p53;Tumour Protein p53.
Antigen Type: Recombinant Protein
Antigen Type: TP53
Gene ID: 7157
Primary Accession: P04637
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Other Names:
Antigen NY-CO-13;BCC7;Cellular tumor antigen p53;Cys 51 Stop;FLJ92943;HGNC11998;LFS1; p53;p53 Cellular Tumor Antigen;p53 tumor suppressor;P53_HUMAN;Phosphoprotein p53;Tp53; Transformation related protein 53;TRP53;Tumor protein p53;Tumor suppressor p53;Tumour Protein p53.
Antigen Type: Recombinant Protein
Antigen Type: TP53
Gene ID: 7157
Primary Accession: P04637
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