CSNK2B polyclonal, anti-human, mouse, rat

Background:
Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase Iα, Iγ, Iδ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The a catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.

Alternative Name:
CSNK2B, CK2N, G5A, Casein kinase 2 beta polypeptide, Casein kinase II beta subunit, Casein kinase II subunit beta, CK II beta, CK2B, CK2N, CSK2B, CSK2B, CSNK 2B, csnk2b, G5A, MGC138222, MGC138224, Phosvitin, Protein G5a,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:100
IP:1:10-1:50

Specificity: CSNK2B polyclonal antibody detects endogenous levels of CSNK2B protein.

Immunogen:
Recombinant protein

MW: 25 kDa

Swiss-Prot: P67870(Human) P67871(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.