CST3 monoclonal, anti-human
€470.00
In stock
SKU
AC-AM2096a
Catalog Number: AC-AM2096a
Size: 100 µl
Isotype: mouse IgG1
Clone Name: 572CT4.3.2
Applications: WB
Datasheet
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Size: 100 µl
Isotype: mouse IgG1
Clone Name: 572CT4.3.2
Applications: WB
Datasheet
Request Information
Background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
Other Names:
Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin, CST3
Target/Specificity:
This CST3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 95-122 amino acids from human CST3.
Antigen Region:
95-122
Antigen Type: Synthetic Peptide
Gene Name: CST3
Gene ID: 1471
Primary Accession: P01034
NCBI Accession: NP_000090.1
Other Accession: NP_000090.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease.
Other Names:
Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin, CST3
Target/Specificity:
This CST3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 95-122 amino acids from human CST3.
Antigen Region:
95-122
Antigen Type: Synthetic Peptide
Gene Name: CST3
Gene ID: 1471
Primary Accession: P01034
NCBI Accession: NP_000090.1
Other Accession: NP_000090.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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