CST6 Polyclonal Antibody

Background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Research Area: Cell Biology

Synonyms:
CST 6, CST6, Cystatin 6, Cystatin E, Cystatin E/M, Cystatin M, Cystatin M/E, Cystatin-6, Cystatin-E, Cystatin-M, Cystatin6, CystatinE, CystatinM, Cysteine proteinase inhibitor, CYTM

Immunogen: Recombinant protein of human CST6

Swissprot: Q15828
Gene Accession: BC031334

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-46891