CSTB antibody (clone M2-F1), anti-human
€435.00
In stock
SKU
AC-AT1662a
Catalog Number: AC-AT1662a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IHC, IF
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IHC, IF
Request Information AC-AT1662a">Request Information
Background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Other Names:
Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB, CST6, STFB
Antigen Type:
Recombinant Protein
Gene Name: CSTB
Gene ID: 1476
NCBI Accession: NP_000091.1
Primary Accession: P04080
Other Accession: BC003370.1
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Other Names:
Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB, CST6, STFB
Antigen Type:
Recombinant Protein
Gene Name: CSTB
Gene ID: 1476
NCBI Accession: NP_000091.1
Primary Accession: P04080
Other Accession: BC003370.1
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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