CSTB Polyclonal Antibody

Background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

Research Area: Cancer, Cell Biology

Synonyms:
CHROW21, CPI B, CPI-B, CST 6, CST6, CSTB, Cystatin B (stefin B), Cystatin B, Cystatin-B, CYTB, CYTB, EPM1, EPM1A, Liver thiol proteinase inhibitor, PME, Stefin-B, STF B, STFB, ULD

Immunogen: Synthetic peptide of human CSTB

Swissprot: P04080
Gene Accession: NP_000091

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-33274/sc-66853