CTCF polyclonal, anti-human, mouse, rat, monkey

Background:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Synonyms: MRD21

Cellular Location: Chromosome Nucleus centromere nucleoplasm

Immunogen:
Recombinant protein of human CTCF

Gene Symbol: CTCF

Gene ID: 10664

Swiss prot: P49711

Calculated MW: 83kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-200, IP 1:50-100, ChIP 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.