Ctip2 polyclonal, anti-human

Background:
Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

Alternative Name:
BCL11B, ATL1 alpha, ATL1, ATL1 beta, ATL1 gamma, ATL1-delta, B cell CLL/lymphoma 11B/T cell receptor delta constant region fusion protein, B cell lymphoma/leukemia 11B, B-cell CLL/lymphoma 11B (zinc finger protein), B-cell CLL/lymphoma 11B, B-cell lymphoma/leukemia 11B, BC11B, BCL-11B, Bcl11b, BCL11B/TRDC fusion, COUP TF interacting protein 2, COUP-TF interacting protein 2, COUP-TF-interacting protein 2, Ctip 2, CTIP-2, CTIP2, hRIT1 alpha, hRit1, Radiation induced tumor suppressor gene 1, Radiation induced tumor suppressor gene 1 protein, Radiation-induced tumor suppressor gene 1 protein, Rit 1, Rit1, zinc finger protein hRit1 alpha, ZNF856B,

Application Dilution:
WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: Ctip2 polyclonal antibody detects endogenous levels of Ctip2 protein.

Immunogen:
recombinant protein

MW: 100/110kDa

Swiss-Prot: Q9C0K0(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.