CTLA4 antibody (clone 1F4), anti-human
€435.00
In stock
SKU
AC-AT1670a
Catalog Number: AC-AT1670a
Size: 50 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 50 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT1670a">Request Information
Background:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Other Names:
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152
Antigen Type:
Recombinant Protein
Gene Name: CTLA4
Gene ID: 1493
NCBI Accession: NP_001032720.1;NP_005205.2
Primary Accession: P16410
Other Accession: NM_005214
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Other Names:
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152
Antigen Type:
Recombinant Protein
Gene Name: CTLA4
Gene ID: 1493
NCBI Accession: NP_001032720.1;NP_005205.2
Primary Accession: P16410
Other Accession: NM_005214
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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