CTLA4 polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP10465A
Catalog Number: AC-AP10465A
Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB23352
Applications: WB, IHC-P
Datasheet
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Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB23352
Applications: WB, IHC-P
Datasheet
Request Information
Background:
CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to Tcells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Other Names:
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152, IDDM12
Target/Specificity:
This IDDM12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids of human IDDM12.
Antigen Region:
50-78
Antigen Type: Synthetic Peptide
Gene Name: CTLA4
Gene ID: 1493
Primary Accession: P16410
NCBI Accession: NP_001032720.1;NP_005205.2
Other Accession: NP_005205.2;NP_001032720.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to Tcells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Other Names:
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152, IDDM12
Target/Specificity:
This IDDM12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids of human IDDM12.
Antigen Region:
50-78
Antigen Type: Synthetic Peptide
Gene Name: CTLA4
Gene ID: 1493
Primary Accession: P16410
NCBI Accession: NP_001032720.1;NP_005205.2
Other Accession: NP_005205.2;NP_001032720.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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