CTNNA1 Polyclonal Antibody

Background:
Catenin alpha-1is aproteinthat in humans is encoded by theCTNNA1gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be mucHuman, Mouseore dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.

Research Area: Cancer, Signal Transduction, Stem Cells

Synonyms:
Alpha E-catenin, Cadherin associated protein 102kDa, Cadherin associated protein, Cadherin-associated protein, CAP 102, CAP102, Catenin (cadherin associated protein) alpha 1 102kDa, Catenin (cadherin associated protein), alpha 1, 102kDa, Catenin alpha 1, Catenin alpha-1, CTNA1, CTNNA 1, Ctnna1, FLJ36832, FLJ52416, MDPT2, NY REN 13 antigen, OTTHUMP00000224141, OTTHUMP00000224147, Renal carcinoma antigen NY REN 13, Renal carcinoma antigen NY-REN-13

Immunogen: Recombinant protein of human CTNNA1

Swissprot: P35221
Gene Accession: BC031262

Calculated MW: 100 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-1495/sc-7894