CTNNB1 antibody (clone 1000), anti-human
€435.00
In stock
SKU
AC-AT1675a
Catalog Number: AC-AT1675a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT1675a">Request Information
Background:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Other Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Antigen Type:
Recombinant Protein
Gene Name: CTNNB1 (HGNC:2514)
Gene ID: 1499
NCBI Accession: NP_001091679.1;NP_001091680.1;NP_001895.1
Primary Accession: P35222
Other Accession: NM_001904
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Other Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Antigen Type:
Recombinant Protein
Gene Name: CTNNB1 (HGNC:2514)
Gene ID: 1499
NCBI Accession: NP_001091679.1;NP_001091680.1;NP_001895.1
Primary Accession: P35222
Other Accession: NM_001904
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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