CTNNB1 monoclonal (Ascites), anti-human
€470.00
In stock
SKU
AC-AM2074a
Catalog Number: AC-AM2074a
Size: 100 µl
Isotype: mouse IgM
Clone Name: 516CT4.3.3
Applications: WB
Datasheet
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Size: 100 µl
Isotype: mouse IgM
Clone Name: 516CT4.3.3
Applications: WB
Datasheet
Request Information
Background:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Other Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Target/Specificity:
This CTNNB1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 646-673 amino acids from human CTNNB1.
Antigen Region:
646-673
Antigen Type: Synthetic Peptide
Gene Name: CTNNB1 (HGNC:2514)
Gene ID: 1499
Primary Accession: P35222
NCBI Accession: NP_001091679.1;NP_001091680.1;NP_001895.1
Other Accession: P26233; Q9WU82; Q02248; Q0VCX4; P18824; NP_001091679.1; F1QGH7
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Other Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Target/Specificity:
This CTNNB1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 646-673 amino acids from human CTNNB1.
Antigen Region:
646-673
Antigen Type: Synthetic Peptide
Gene Name: CTNNB1 (HGNC:2514)
Gene ID: 1499
Primary Accession: P35222
NCBI Accession: NP_001091679.1;NP_001091680.1;NP_001895.1
Other Accession: P26233; Q9WU82; Q02248; Q0VCX4; P18824; NP_001091679.1; F1QGH7
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
| Is Featured? | No |
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