CTNNB1 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Synonyms: CTNNB, MRD19, armadillo

Cellular Location: Cell junction Cell membrane Cytoplasm Nucleus adherens junction centrosome cytoskeleton microtubule organizing center spindle pole

Immunogen:
A synthetic peptide of human CTNNB1

Gene Symbol: CTNNB1

Gene ID: 1499

Swiss prot: P35222

Calculated MW: 85kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.