CTTN polyclonal, anti-human

Background:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Synonyms: EMS1,cortactin

Cellular Location: Cytoplasm

Immunogen:
A synthetic peptide of human CTTN

Gene Symbol: CTTN

Gene ID: 2017

Swiss prot: Q14247

Calculated MW: 62/71/57kDa

Recommended dilution:
WB 1:8000-12000, IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.