CTTN polyclonal (Center), anti-human
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In stock
SKU
AC-AP13727c
Catalog Number: AC-AP13727c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33698
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33698
Applications: IHC-P, WB
Datasheet
Request Information
Background:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Other Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Target/Specificity:
This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.
Antigen Region:
273-302
Antigen Type: Synthetic Peptide
Gene Name: CTTN
Gene ID: 2017
Primary Accession: Q14247
NCBI Accession: NP_001171669.1;NP_005222.2;NP_612632.1
Other Accession: Q01406; NP_005222.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Other Names:
Src substrate cortactin, Amplaxin, Oncogene EMS1, CTTN, EMS1
Target/Specificity:
This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.
Antigen Region:
273-302
Antigen Type: Synthetic Peptide
Gene Name: CTTN
Gene ID: 2017
Primary Accession: Q14247
NCBI Accession: NP_001171669.1;NP_005222.2;NP_612632.1
Other Accession: Q01406; NP_005222.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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