CUL2 polyclonal (N-term), anti-human, mouse
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In stock
SKU
AC-AP16900a
Catalog Number: AC-AP16900a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33843
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33843
Applications: WB
Datasheet
Request Information
Background:
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Other Names:
Cullin-2, CUL-2, CUL2
Target/Specificity:
This CUL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the N-terminal region of human CUL2.
Antigen Region:
150-179
Antigen Type: Synthetic Peptide
Gene Name: CUL2 (HGNC:2552)
Gene ID: 8453
Primary Accession: Q13617
NCBI Accession: NP_001185706.1;NP_001185707.1;NP_001185708.1;NP_003582.2
Other Accession: Q9D4H8; NP_003582.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Other Names:
Cullin-2, CUL-2, CUL2
Target/Specificity:
This CUL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the N-terminal region of human CUL2.
Antigen Region:
150-179
Antigen Type: Synthetic Peptide
Gene Name: CUL2 (HGNC:2552)
Gene ID: 8453
Primary Accession: Q13617
NCBI Accession: NP_001185706.1;NP_001185707.1;NP_001185708.1;NP_003582.2
Other Accession: Q9D4H8; NP_003582.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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