CUL4A polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS7446
Background:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC.
Alternative Name:
2810470J21Rik, AW495282, CUL 4A, CUL-4A, Cul4a, Cul4a protein, CUL4A_HUMAN, Cullin-4A, MGC36573, MGC64071,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: CUL4A polyclonal antibody detects endogenous levels of CUL4A protein.
Immunogen:
Recombinant full length Human CUL4A.
MW: ~88 kDa
Swis Prot.: Q13619
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC.
Alternative Name:
2810470J21Rik, AW495282, CUL 4A, CUL-4A, Cul4a, Cul4a protein, CUL4A_HUMAN, Cullin-4A, MGC36573, MGC64071,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: CUL4A polyclonal antibody detects endogenous levels of CUL4A protein.
Immunogen:
Recombinant full length Human CUL4A.
MW: ~88 kDa
Swis Prot.: Q13619
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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