Cullin 2 polyclonal, anti-human, mouse
€470.00
In stock
SKU
AC-AP50189
Catalog Number: AC-AP50189
Size: 100 µl
Host: Rabbit
Applications: WB, IF, IHC
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IF, IHC
Datasheet
Request Information
Background:
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Other Names:
Cullin-2, CUL-2, CUL2
Antigen Type: Synthetic Peptide
Antigen Type: CUL2 (HGNC:2552)
Gene ID: 8453
Primary Accession: Q13617
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
Other Names:
Cullin-2, CUL-2, CUL2
Antigen Type: Synthetic Peptide
Antigen Type: CUL2 (HGNC:2552)
Gene ID: 8453
Primary Accession: Q13617
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