CUTA Polyclonal Antibody

Background:
CUTA, also known as ACHAP (acetylcholinesterase-associated protein), is the 179 amino acid mammalian homolog of the cutA E. coli protein and is ubiquitously expressed, particularly in brain tissue. Existing as multiple alternatively spliced isoforms, CUTA functions as a homotrimer that is thought to act as a component of an acetylcholinesterase (AChE)-attached complex, suggesting an involvement in AChE regulation. The gene encoding CUTA maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

Research Area: Cell Biology

Synonyms:
Acetylcholinesterase Associated Protein, Acetylcholinesterase-associated protein, ACHAP, Brain acetylcholinesterase putative membrane anchor, C6ORF82, cutA, CutA Divalent Cation Tolerance Homolog , cutA divalent cation tolerance homolog (E. coli), CUTA, CutA1, divalent cation tolerant protein CUTA, MGC111154, OTTHUMP00000039621, Protein CutA, RP4570F34

Immunogen: Fusion protein of human CUTA

Swissprot: O60888
Gene Accession: BC005890

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.